PRIME PubMed | Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports (2024)

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PRIME PubMed | Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports (1)

Abstract

Recently, health hazards, such as kidney damage, have been reported owing to the ingestion of a health food product, so-called "foods with functional claims (FFC)'', containing beni-koji (red yeast rice). Although not an expected compound in the FFC, the detection of puberulic acid has also been reported. Further investigations of these health food products, such as the identification of other unintended compounds and clarifying the health impacts of puberulic acid, are required. To clarify the causes of these health issues, we investigated the presence of unintended compounds in the FFC containing beni-koji using comprehensive instrumental analyses. Using differential analysis, novel compounds 1 and 2 were detected as unexpected components between the samples with and without adverse event reports. Although limited to the samples available for analyses in this study, both compounds 1 and 2 were detected in all the samples that also contained puberulic acid. Compounds 1 and 2, with molecular formulas of C23H34O7 and C28H42O8, respectively, may be lovastatin derivatives. Their structures were confirmed using NMR analyses and are novel natural compounds. For definitive confirmation, we are in the process of synthesizing compounds 1 and 2 from lovastatin. The route of contamination of these compounds are currently under investigation. The findings of this study could be used to address the growing health hazards associated with health food products.

Authors+Show Affiliations

Tanaka S

National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.

Masumoto N

National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.

Makino T

Central R& D Laboratory, Kobayashi Pharmaceutical Co., Ltd., 1-30-3, Toyokawa, Ibaraki-City, Osaka, 567-0057, Japan.

Matsushima Y

Central R& D Laboratory, Kobayashi Pharmaceutical Co., Ltd., 1-30-3, Toyokawa, Ibaraki-City, Osaka, 567-0057, Japan.

Morikawa T

Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.

Ito M

National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan. michiho_ito@nihs.go.jp.

MeSH

Biological ProductsHumansFunctional FoodMolecular StructureLovastatinMagnetic Resonance Spectroscopy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

38834898

Citation

Tanaka, Seiji, et al. "Novel Compounds Isolated From Health Food Products Containing Beni-koji (red Yeast Rice) With Adverse Event Reports." Journal of Natural Medicines, vol. 78, no. 4, 2024, pp. 845-848.

Tanaka S, Masumoto N, Makino T, et al. Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports. J Nat Med. 2024;78(4):845-848.

Tanaka, S., Masumoto, N., Makino, T., Matsushima, Y., Morikawa, T., & Ito, M. (2024). Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports. Journal of Natural Medicines, 78(4), 845-848. https://doi.org/10.1007/s11418-024-01827-w

Tanaka S, et al. Novel Compounds Isolated From Health Food Products Containing Beni-koji (red Yeast Rice) With Adverse Event Reports. J Nat Med. 2024;78(4):845-848. PubMed PMID: 38834898.

* Article titles in AMA citation format should be in sentence-case

TY - JOURT1 - Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports.AU - Tanaka,Seiji,AU - Masumoto,Naoko,AU - Makino,Takuya,AU - Matsushima,Yuji,AU - Morikawa,Toshio,AU - Ito,Michiho,Y1 - 2024/06/04/PY - 2024/05/31/receivedPY - 2024/06/03/acceptedPY - 2024/8/31/medlinePY - 2024/6/5/pubmedPY - 2024/6/4/entrezKW - Monascus pilosusKW - Beni-kojiKW - Comprehensive analysisKW - Health food productKW - Health hazardKW - Lovastatin derivativesSP - 845EP - 848JF - Journal of natural medicinesJO - J Nat MedVL - 78IS - 4N2 - Recently, health hazards, such as kidney damage, have been reported owing to the ingestion of a health food product, so-called "foods with functional claims (FFC)'', containing beni-koji (red yeast rice). Although not an expected compound in the FFC, the detection of puberulic acid has also been reported. Further investigations of these health food products, such as the identification of other unintended compounds and clarifying the health impacts of puberulic acid, are required. To clarify the causes of these health issues, we investigated the presence of unintended compounds in the FFC containing beni-koji using comprehensive instrumental analyses. Using differential analysis, novel compounds 1 and 2 were detected as unexpected components between the samples with and without adverse event reports. Although limited to the samples available for analyses in this study, both compounds 1 and 2 were detected in all the samples that also contained puberulic acid. Compounds 1 and 2, with molecular formulas of C23H34O7 and C28H42O8, respectively, may be lovastatin derivatives. Their structures were confirmed using NMR analyses and are novel natural compounds. For definitive confirmation, we are in the process of synthesizing compounds 1 and 2 from lovastatin. The route of contamination of these compounds are currently under investigation. The findings of this study could be used to address the growing health hazards associated with health food products. SN - 1861-0293UR - https://www.unboundmedicine.com/medline/citation/38834898/Novel_compounds_isolated_from_health_food_products_containing_beni-koji_DB - PRIMEDP - Unbound MedicineER -

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PRIME PubMed | Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports (2024)

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